Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/9100
Title: Modification of electrospun PVA/PAA scaffolds by cold atmospheric plasma: alignment, antibacterial activity, and biocompatibility
Authors: Arik, Nehir
İnan, Alper
İbiş, Fatma
Demirci, Emine A.
Karaman, Ozan
Ercan, Utku K.
Horzum, Nesrin
Keywords: Alignment
Cold atmospheric plasma
Electrospinning
Nanofibrous scaffold
Issue Date: 2019
Publisher: Springer Verlag
Abstract: The ongoing search for better antibacterial wound care dressings has led to the design and fabrication of advanced functional nanomaterials. Taking advantage of electrospinning and cold atmospheric plasma (CAP), free-standing nanofibrous scaffolds are promising for use in novel biomedical applications. Random and aligned polyvinyl alcohol (PVA)/polyacrylic acid (PAA) nanofiber scaffolds are fabricated by electrospinning and treated with CAP. In this study, we investigate the effects of CAP treatment on alignment, hydrophilicity, antibacterial activity, and biocompatibility in determining the surface properties of the nanofibrous scaffolds. The results of vibrational polarization spectroscopy analysis indicate that CAP treatment changes the degree of alignment of the nanofibers. Furthermore, both random and aligned CAP-treated nanofibrous scaffolds show significant antibacterial activity against the E. coli strain. The results of an in vitro scratch assay reveal that CAP treatment of PVA/PAA nanofibers has no toxic effect.
URI: https://doi.org/10.1007/s00289-018-2409-8
https://hdl.handle.net/11147/9100
ISSN: 0170-0839
1436-2449
Appears in Collections:Chemistry / Kimya
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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