Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/9122
Title: CNT Incorporated Polyacrilonitrile/Polypyrrole Nanofibers as Keratinocytes Scaffold
Authors: Yardımcı, Atike İnce
Aypek, Hande
Öztürk, Özgür
Yılmaz, Selahattin
Özçivici, Engin
Meşe, Gülistan
Selamet, Yusuf
Keywords: Polypyrrole
carbon nanotube (CNT)
electrospinning
biocompatibility
keratinocyte
Issue Date: 2019
Publisher: Trans Tech Publications
Abstract: Polypyrrole (PPy) is an attractive scaffold material for tissue engineering with its non-toxic and electrically conductive properties. There has not been enough information about PPy usage in skin tissue engineering. The aim of this study is to investigate biocompatibility of polyacrilonitrile (PAN)/PPy nanofibrous scaffold for human keratinocytes. PAN/PPy bicomponent nanofibers were prepared by electrospinning, in various PPy concentrations and with carbon nanotube (CNT) incorporation. The average diameter of electrospun nanofibers decreased with increasing PPy concentration. Further, agglomerated CNTs caused beads and disordered parts on the surface of nanofibers. Biocompatibility of these PAN/PPy and PAN/PPy/CNT scaffolds were analyzed in vitro. Both scaffolds provided adhesion and proliferation of keratinocytes. Nanofiber diameter did not significantly influence the morphology of cells. However, with increasing number of cells, cells stayed among nanofibers and this affected their shape and size. In this study, we demonstrated that PAN/PPy and PAN/PPy/CNT scaffolds enabled the growth of keratinocytes, showing their biocompatibility.
Description: WOS: 000465412300006
URI: https://doi.org/10.4028/www.scientific.net/JBBBE.41.69
https://hdl.handle.net/11147/9122
ISSN: 2296-9837
2296-9845
Appears in Collections:WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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