Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/9310
Title: Evaluation of multifunctional hybrid analogs for stilbenes, chalcones and flavanones
Authors: Çağır, Ali
Odacı, Burcu
Varol, Mehmet
Akçok, İsmail
Okur, Özgür
Koparal, Ayşe T.
Keywords: Hybrid molecule
anti-cancer
anti-angiogenic
aromatase inhibition
CYP19
analogs
Issue Date: 2017
Publisher: Bentham Science Publishers B.V.
Abstract: Aims: In this study, discovery of novel anticancer agents acting by more than one mechanism was aimed. Method: For this purpose, eleven previously synthesized simple-stilbene, chalcone, flavanone derivatives and 31 novel stilbene-fused chalcones and stilbene-fused flavanones were tested for their aromatase inhibition, anti-angiogenic and anti-proliferative properties in cancer (PC3, MCF-7) and healthy (HUVEC) cell lines. MTT cell viability assay was used to evaluate the anti-proliferative activities of the compounds. CYP19/MFC high-throughput screening kit (BD Biosciences, Oxford, UK) was used to search the aromatase inhibition properties and matrigel tube formation assay was applied to determine the anti-angiogenic activities. Results: Results indicate that the simple-chalcone and flavanone derivatives were more cytotoxic than the simple-stilbenes in the both cancer cell lines. In contrast, the simple-stilbene structures were much more effective at aromatase inhibition. The cytotoxicity profiles of stilbene-fused chalcones in cancer cells imply that these molecules mostly mimic the simple chalcone structures. On the other hand, flavanones lose their cytotoxic activities after becoming fused with stilbenes. Additionally, aromatase inhibition assays showed that stilbene-fused chalcones again do mimic the simple-chalcones but not simple-stilbenes and anti-angiogenic profiles of the tested molecules seem to be not related with stilbene fragments. Furthermore, stilbene-fused flavanones may mimic both simple-flavanones and simple-stilbenes depending upon the type and position of the substituent in their respective terminal aromatic rings.
Description: Akcok, Ismail/0000-0002-5444-3929; Cagir, Ali/0000-0003-0347-6656; VAROL, Mehmet/0000-0003-2565-453X
WOS: 000424633600005
PubMed: 28554313
URI: https://doi.org/10.2174/1871520617666170530091223
https://hdl.handle.net/11147/9310
ISSN: 1871-5206
1875-5992
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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