Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/9373
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dc.contributor.authorKhan, H. Y.-
dc.contributor.authorLi, Y.-
dc.contributor.authorAboukameel, A.-
dc.contributor.authorMpilla, G.-
dc.contributor.authorSexton, R.-
dc.contributor.authorKanbur, Tuğçe-
dc.contributor.authorNagasaka, M.-
dc.contributor.authorÇetinkaya, Hakkı-
dc.contributor.authorÇağır, Ali-
dc.date.accessioned2020-07-25T22:10:43Z-
dc.date.available2020-07-25T22:10:43Z-
dc.date.issued2020-
dc.identifier.issn1556-0864-
dc.identifier.issn1556-1380-
dc.identifier.urihttps://hdl.handle.net/11147/9373-
dc.description.abstractMutations in KRAS are among the most common aberrations in cancer. However, despite considerable research efforts, KRAS remains a challenging therapeutic target. In recent years, there has been a drive to develop KRAS mutant specific drugs. Among the different known mutations, the KRASG12C (glycine 12 to cysteine) has been considered druggable. Studies have shown that due in part to the close proximity of Cysteine 12 to both the nucleotide pocket and the switch regions, thiol-reactive compounds can bind to the active site covalently and inhibit KRASG12C mutation-driven signaling. The absence of this particular cysteine residue in wild-type KRAS makes such an approach very selective towards cancer cells.en_US
dc.language.isoenen_US
dc.publisherInternational Association for the Study of Lung Canceren_US
dc.relation.ispartofJournal of Thoracic Oncologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectKRASen_US
dc.subjectLung canceren_US
dc.titleA novel inhibitor for KRASG12C mutant lung carcinomaen_US
dc.typeConference Objecten_US
dc.institutionauthorKanbur, Tuğçe-
dc.institutionauthorÇetinkaya, Hakkı-
dc.institutionauthorÇağır, Ali-
dc.departmentİzmir Institute of Technology. Chemistryen_US
dc.identifier.volume15en_US
dc.identifier.issue2en_US
dc.identifier.startpageS15en_US
dc.identifier.endpageS15en_US
dc.identifier.wosWOS:000509464500039en_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.identifier.wosqualityQ1-
dc.identifier.scopusqualityQ1-
item.openairetypeConference Object-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextopen-
crisitem.author.dept01. Izmir Institute of Technology-
crisitem.author.dept04.01. Department of Chemistry-
Appears in Collections:Chemistry / Kimya
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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