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Title: A new semi-synthetic sapogenol derivative inducing regulated necrosis
Authors: Üner, Göklem
Ballar Kırmızıbayrak, Petek
Bedir, Erdal
Issue Date: 2019
Publisher: Georg Thieme Verlag
Abstract: Since saponin’s antitumor potency is relatively weak, researchers focus on their semi-synthetic modification to obtain structures with higher potencies. With the same motivation, we prepared a cytotoxic sapogenol derivative (AG-08) from cycloastragenol. Our preliminary studies revealed that AG-08 induced primarily necrotic cell death along with autophagic inhibition. Furthermore, immunoblotting experiments demonstrated that AG-08 promoted cleavage of various proteins such as ATGs, p62, and PARP-1.
Description: 67th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA) -- SEP 01-05, 2019 -- Innsbruck, AUSTRIA
ISSN: 0032-0943
Appears in Collections:Bioengineering / Biyomühendislik
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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