Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/9381
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dc.contributor.authorÜner, Göklem-
dc.contributor.authorBallar Kırmızıbayrak, Petek-
dc.contributor.authorBedir, Erdal-
dc.date.accessioned2020-07-25T22:10:43Z-
dc.date.available2020-07-25T22:10:43Z-
dc.date.issued2019-
dc.identifier.issn0032-0943-
dc.identifier.issn1439-0221-
dc.identifier.urihttps://doi.org/10.1055/s-0039-3399943-
dc.identifier.urihttps://hdl.handle.net/11147/9381-
dc.description67th International Congress and Annual Meeting of the Society-for-Medicinal-Plant-and-Natural-Product-Research (GA) -- SEP 01-05, 2019 -- Innsbruck, AUSTRIAen_US
dc.description.abstractSince saponin’s antitumor potency is relatively weak, researchers focus on their semi-synthetic modification to obtain structures with higher potencies. With the same motivation, we prepared a cytotoxic sapogenol derivative (AG-08) from cycloastragenol. Our preliminary studies revealed that AG-08 induced primarily necrotic cell death along with autophagic inhibition. Furthermore, immunoblotting experiments demonstrated that AG-08 promoted cleavage of various proteins such as ATGs, p62, and PARP-1.en_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlagen_US
dc.relation.ispartofPlanta Medicaen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titleA new semi-synthetic sapogenol derivative inducing regulated necrosisen_US
dc.typeConference Objecten_US
dc.institutionauthorÜner, Göklem-
dc.institutionauthorBedir, Erdal-
dc.departmentİzmir Institute of Technology. Bioengineeringen_US
dc.identifier.volume85en_US
dc.identifier.issue18en_US
dc.identifier.startpage1507en_US
dc.identifier.endpage1507en_US
dc.identifier.wosWOS:000503772900316en_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1055/s-0039-3399943-
dc.relation.doi10.1055/s-0039-3399943en_US
dc.coverage.doi10.1055/s-0039-3399943en_US
dc.identifier.wosqualityQ1-
dc.identifier.scopusqualityQ1-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeConference Object-
item.languageiso639-1en-
item.fulltextNo Fulltext-
crisitem.author.dept01. Izmir Institute of Technology-
crisitem.author.dept03.01. Department of Bioengineering-
Appears in Collections:Bioengineering / Biyomühendislik
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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