Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/9392
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dc.contributor.authorDelikoyun, Kerem-
dc.contributor.authorYaman, Sena-
dc.contributor.authorAnıl İnevi, Müge-
dc.contributor.authorÖzçivici, Engin-
dc.contributor.authorTekin, Hüseyin Cumhur-
dc.date.accessioned2020-07-25T22:10:44Z-
dc.date.available2020-07-25T22:10:44Z-
dc.date.issued2019-
dc.identifier.isbn978-1-7281-2420-9-
dc.identifier.urihttps://hdl.handle.net/11147/9392-
dc.descriptionMedical Technologies Congress (TIPTEKNO) -- OCT 03-05, 2019 -- Izmir, TURKEYen_US
dc.description.abstractSeparation of target cells in a heterogeneous solution is of great importance for clinical studies especially for immunology and oncology. Separated cells can be used for diagnostic applications ranging from whole blood counting to isolation of circulating tumor cells (CTC) for personalized medicine. Recent separation technologies rely on labelling and identifying target cells with variety of labelling principle such as fluorescence or magnetic tags. However, they require labor-intensive processes, long analysis time, and expensive chemical reagents and instrumentation. Hence, their usage is limited to well-equipped centralized laboratories. There is a need for a rapid, sensitive, low-cost and automated cell separation technology to disseminate usage of this technology even in rural areas. Magnetic levitation is a powerful cell separation method, which distinguishes cells based on their levitation heights depending on cell density. However, magnetic levitation-based separation technologies require traditional, bulky and expensive microscopes for analysis. Lensless digital inline holographic microscopy (LDIHM) systems are composed of a simple illumination system containing an LED, a pinhole, and an imaging sensor for high-resolution microscopic imaging, which eliminates needs of highly fragile and expensive optics as in traditional microscopy. Here, we introduced a novel hybrid and portable cell separation platform, where magnetic levitation technology is integrated with LDIHM system for automated analysis of cell levitation heights. Using this platform, three different cell lines are successfully separated. Live and dead cells having distinguished levitation heights can be also identified in the platform.en_US
dc.language.isoenen_US
dc.publisherInstitute of Electrical and Electronics Engineers Inc.en_US
dc.relation.ispartof2019 Medical Technologies Congress (TIPTEKNO)en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCell separationen_US
dc.subjectMagnetic levitationen_US
dc.subjectDensity measurementen_US
dc.subjectLensless digital inline holographic microscopyen_US
dc.subjectPortable analysisen_US
dc.titleCell separation with hybrid magnetic levitation-based lensless holographic microscopy platformen_US
dc.typeConference Objecten_US
dc.institutionauthorDelikoyun, Kerem-
dc.institutionauthorYaman, Sena-
dc.institutionauthorAnıl İnevi, Müge-
dc.institutionauthorÖzçivici, Engin-
dc.institutionauthorTekin, Hüseyin Cumhur-
dc.departmentİzmir Institute of Technology. Bioengineeringen_US
dc.identifier.startpage82en_US
dc.identifier.endpage85en_US
dc.identifier.wosWOS:000516830900022en_US
dc.identifier.scopus2-s2.0-85075627011en_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.openairetypeConference Object-
crisitem.author.dept03.01. Department of Bioengineering-
crisitem.author.dept03.01. Department of Bioengineering-
crisitem.author.dept03.01. Department of Bioengineering-
crisitem.author.dept03.01. Department of Bioengineering-
crisitem.author.dept03.01. Department of Bioengineering-
Appears in Collections:Bioengineering / Biyomühendislik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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