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Title: Lensless digital in-line holographic microscopy for space biotechnology applications
Authors: Delikoyun, Kerem
Çine, Ersin
Anıl İnevi, Müge
Özuysal, Mustafa
Özçivici, Engin
Tekin, Hüseyin Cumhur
Keywords: Holographic microscopy
Lensless imaging
Cell culture
Issue Date: 2019
Publisher: Institute of Electrical and Electronics Engineers Inc.
Abstract: Biomechanical changes at cellular level can dramatically affect living organisms in both aviation and space applications. Weightlessness induces morphological alteration of cells, which leads to tissue loss. Therefore, scientists have been studying the effect of weightlessness using cell culture based biological experiments using conventional microscopes. However, strict requirements regarding cost, weight and functionality limit the use of conventional microscopes in space environment. Lensless digital in-line holographic microscopy enables to use low-weight, low-cost and robust elements, such as a light emitting diode (LED), an aperture and an imaging sensor, instead of bulky, expensive and fragile optical elements, such as lenses, mirrors and filters. This technology offers a high field of view compared to conventional microscopes without affecting the resolution and it is also suitable for remote sensing applications with automated imaging capabilities. Here, we present a portable digital in-line holographic microscopy platform that allows to visualize cells and to analyze their viability in a microfluidic chip. The platform offers microscopic imaging with 1.55 mu m spatial resolution, 21.7 mm(2) field of view and image coloring capability. This platform could potentially play an important role in space biotechnology applications by enabling low-cost, high-resolution and portable monitoring of cells.
Description: 9th International Conference on Recent Advances in Space Technologies (RAST) -- JUN 11-14, 2019 -- Istanbul, TURKEY
ISBN: 978-1-5386-9448-0
Appears in Collections:Bioengineering / Biyomühendislik
Computer Engineering / Bilgisayar Mühendisliği
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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