Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/9455
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dc.contributor.authorJilkova, Z. M.-
dc.contributor.authorZeybek Kuyucu, Ayça-
dc.contributor.authorKurma, K.-
dc.contributor.authorPour, S. T. A.-
dc.contributor.authorRoth, G. S.-
dc.contributor.authorAbbadessa, G.-
dc.contributor.authorDecaens, T.-
dc.date.accessioned2020-07-25T22:12:32Z-
dc.date.available2020-07-25T22:12:32Z-
dc.date.issued2017-
dc.identifier.issn0168-8278-
dc.identifier.issn1600-0641-
dc.identifier.urihttps://doi.org/10.1016/S0168-8278(17)31736-1-
dc.identifier.urihttps://hdl.handle.net/11147/9455-
dc.descriptionInternational Liver Congress / 52nd Annual Meeting of the European-Association-for-the-Study-of-the-Liver -- APR 19-23, 2017 -- Amsterdam, NETHERLANDSen_US
dc.description.abstractBackground and Aims: Hepatocellular carcinoma (HCC) is often diagnosed at advanced stages with limited number of therapeutic options. Longer exposure to classical treatment of advanced HCC, sorafenib, often over-activates AKT pathway, leading to HCC resistance. Moreover, AKT pathway itself is activated in almost half of HCC cases. Therefore, we investigated the efficacy of combination of Sorafenib with allosteric Akt inhibitor ARQ 092 in a DEN-induced cirrhotic rat model with HCC.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Hepatologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleAKT inhibitor ARQ 092 and sorafenib additively inhibit progression of hepatocellular carcinoma and improve immune system in cirrhotic rat modelen_US
dc.typeConference Objecten_US
dc.institutionauthorZeybek Kuyucu, Ayça-
dc.departmentİzmir Institute of Technology. Bioengineeringen_US
dc.identifier.volume66en_US
dc.identifier.issue1en_US
dc.identifier.startpageS641en_US
dc.identifier.endpageS641en_US
dc.identifier.wosWOS:000401056601578en_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/S0168-8278(17)31736-1-
dc.relation.doi10.1016/S0168-8278(17)31736-1en_US
dc.coverage.doi10.1016/S0168-8278(17)31736-1en_US
local.message.claim2022-06-09T09:56:55.140+0300|||rp03017|||submit_approve|||dc_contributor_author|||None*
dc.identifier.wosqualityQ1-
dc.identifier.scopusqualityQ1-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeConference Object-
item.languageiso639-1en-
item.fulltextWith Fulltext-
crisitem.author.dept03.01. Department of Bioengineering-
Appears in Collections:Bioengineering / Biyomühendislik
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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