Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/9456
Title: Microbial transformation of ruscogenins by Cunninghamella blakesleeana
Authors: Özçınar, Özge
Tağ, Özgür
Kıvçak, Bijen
Bedir, Erdal
Keywords: Microbial transformation
Ruscogenin
Neoruscogenin
Cunninghamella blakesleeana
Issue Date: 2016
Publisher: Georg Thieme Verlag
Abstract: The natural product drug discovery process involves the isolation of new molecules from natural sources, investigation of their biological activities, and semi-synthesis of more active analogs. Microbial transformation plays a vital role in the preparation of new oxygenated derivatives, and has frequently been used as microbial model of mammalian drug metabolism [1,2]. It has been proved that the hydroxylation of steroidal compounds is catalyzed by cytochrome P450 monoxygenase systems, which exist in all eucaryotic microorganisms [3]. Cunninghamella genus has been widely used in transformation of steroids [4,5]. The major steroidal saponins of Ruscus aculeatus, ruscogenin and neoruscogenin, has strong anti-inflammatory activities, acts as an anti-elastase, and decreases capillary permeability [6]. In the present study microbial transformation of Neoruscogenin:Ruscogenin (78:22) mixture by Cunninghamella blakesleeana fungus afforded three new compounds. The structures were elucidated by LC-MS, 1D- and 2D NMR analyses as shown below. Mainly oxydation products were obtained from neoruscogenin by C. blakesleana. As far as can be ascertained from the literature, this is the first microbial transformation study performed on neoruscogenin.
Description: 9th Joint Meeting of AFERP, ASP, GA, JSP, PSE and SIF -- JUL 24-27, 2016 -- Copenhagen, DENMARK
URI: https://doi.org/10.1055/s-0036-1596771
https://hdl.handle.net/11147/9456
ISSN: 0032-0943
1439-0221
Appears in Collections:Bioengineering / Biyomühendislik
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Show full item record



CORE Recommender

WEB OF SCIENCETM
Citations

1
checked on Feb 17, 2024

Page view(s)

106
checked on Feb 19, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.