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https://hdl.handle.net/11147/9462
Title: | Deletion of sialidase NEU3 causes progressive neurodegeneration in Tay-Sachs mice | Authors: | Seyrantepe, Volkan | Issue Date: | 2016 | Publisher: | Academic Press | Abstract: | Tay-Sachs disease is a severe lysosomal disorder caused by mutations in the HEXA gene coding for α subunit of lysosomal βhexosaminidase A which converts GM2 to GM3 ganglioside. HexA-/-mice, depleted of β-hexosaminidase A gene, remains asymptomatic to 1 year of age, owing to the ability of these mice to catabolise stored GM2 ganglioside via sialidase(s) removing sialic acid into glycolipid GA2 which further processed by β-Hexosaminidase B, thereby bypassing the HexA defect. | Description: | 12th Annual WORLD Symposium -- FEB 29-MAR 04, 2016 -- San Diego, CA | URI: | https://doi.org/10.1016/j.ymgme.2015.12.434 https://hdl.handle.net/11147/9462 |
ISSN: | 1096-7192 1096-7206 |
Appears in Collections: | Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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1-s2.0-S1096719215006198-main.pdf | 50.95 kB | Adobe PDF | View/Open |
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