Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/9506
Title: The role of cysteine cathepsins in cancer progression and drug resistance
Authors: Rudzinska, Magdalena
Parodi, Alessandro
Soond, Surinder M.
Vinarov, Andrey Z.
Korolev, Dmitry O.
Morozov, Andrey O.
Zamyatnin, Andrey A., Jr.
Dağlıoğlu, Cenk
Tutar, Yusuf
Keywords: Cysteine cathepsins
Cancer progression
Drug resistance
Publisher: MDPI
Abstract: Cysteine cathepsins are lysosomal enzymes belonging to the papain family. Their expression is misregulated in a wide variety of tumors, and ample data prove their involvement in cancer progression, angiogenesis, metastasis, and in the occurrence of drug resistance. However, while their overexpression is usually associated with highly aggressive tumor phenotypes, their mechanistic role in cancer progression is still to be determined to develop new therapeutic strategies. In this review, we highlight the literature related to the role of the cysteine cathepsins in cancer biology, with particular emphasis on their input into tumor biology.
Description: PubMed: 31340550
URI: https://doi.org/10.3390/ijms20143602
https://hdl.handle.net/11147/9506
ISSN: 1422-0067
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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