Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/9592
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dc.contributor.authorKhan, Nasar-
dc.contributor.authorYılmaz, Sinem-
dc.contributor.authorAksoy, Semiha-
dc.contributor.authorUzel, Ataç-
dc.contributor.authorTosun, Çiğdem-
dc.contributor.authorBallar Kırmızıbayrak, Petek-
dc.contributor.authorBedir, Erdal-
dc.date.accessioned2020-07-25T22:17:43Z-
dc.date.available2020-07-25T22:17:43Z-
dc.date.issued2019-
dc.identifier.issn0009-2797-
dc.identifier.issn1872-7786-
dc.identifier.urihttps://doi.org/10.1016/j.cbi.2019.04.035-
dc.identifier.urihttps://hdl.handle.net/11147/9592-
dc.description.abstractPolyether compounds, a large group of biologically active metabolites produced by Streptomyces species have been reported to show a variety of bioactivity such as antibacterial, antifungal, antiparasitic, antiviral, and tumour cell cytotoxicity. Since some of these compounds target cancer stem cells and multi-drug resistant cancer cells, this family of compounds have become of high interest. In this study, three polyether-type metabolites (1-3), one of which was a new natural product (3), were isolated from the marine derived Streptomyces cacaoi via antimicrobial activity-guided fractionation studies. As several polyether compounds with structural similarity such as monensin have been linked with autophagy and cell death, we first assessed the cytotoxicity of these three compounds. Compounds 2 and 3, but not 1, were found to be cytotoxic in several cell lines with a higher potency towards cancer cells. Furthermore, 2 and 3 caused accumulation of both autophagy flux markers LC3-II and p62 along with cleavage of caspase-3, caspase-9 and poly (ADP-ribose) polymerase 1 (PARP-1). Interestingly, prolonged treatment of the compounds caused a dramatic downregulation of the proteins related to autophagasome formation in a dose dependent manner. Our findings provide insights on the molecular mechanisms of the polyether-type polyketides, and signify their potency as chemotherapeutic agents through inhibiting autophagy and inducing apoptosis.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofChemico - Biological Interactionsen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMarine actinobacterium polyether antibioticen_US
dc.subjectAutophagyen_US
dc.subjectApoptosisen_US
dc.titlePolyethers isolated from the marine actinobacterium Streptomyces cacaoi inhibit autophagy and induce apoptosis in cancer cellsen_US
dc.typeArticleen_US
dc.institutionauthorKhan, Nasar-
dc.institutionauthorTosun, Çiğdem-
dc.institutionauthorBedir, Erdal-
dc.departmentİzmir Institute of Technology. Bioengineeringen_US
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume307en_US
dc.identifier.startpage167en_US
dc.identifier.endpage178en_US
dc.identifier.wosWOS:000470976100020en_US
dc.identifier.scopus2-s2.0-85065451130en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.cbi.2019.04.035-
dc.identifier.pmid31059704en_US
dc.relation.doi10.1016/j.cbi.2019.04.035en_US
dc.coverage.doi10.1016/j.cbi.2019.04.035en_US
dc.identifier.wosqualityQ1-
dc.identifier.scopusqualityQ1-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
crisitem.author.dept03.01. Department of Bioengineering-
Appears in Collections:Bioengineering / Biyomühendislik
Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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