Please use this identifier to cite or link to this item:
https://hdl.handle.net/11147/9611
Title: | Soluble cytotoxic ruthenium(II) complexes with 2-hydrazinopyridine | Authors: | Soliman, A. A. Attaby, F. A. Alajrawy, O., I Majeed, S. R. Şahin, C. Varlıklı, Canan |
Keywords: | Ru(II) complexes 2-hydrazinopyridine Antitumor complexes Cytotoxicity DFT calculations |
Publisher: | Pleiades Publishing | Abstract: | New water soluble Ru(II) binary complex [Ru(C5H7N3)(X)(H2O)(2)] with 2-hydrazinopyridine and its ternary complexes with X = dichloride, oxalate, malonate or pyrophosphate ligands have been synthesized. The complexes have been characterized using elemental analyses, mass, IR, and UV-Vis. spectroscopies, cyclic voltammetry, magnetic susceptibility, and thermal analysis. The complexes are diamagnetic and the electronic spectral data showed that peaks are due to low spin octahedral Ru(II) complexes. The optimized structures of the complexes 1-4 indicate distorted octahedral geometry with bond angles around the ruthenium atom ranged from 80.44 degrees to 99.64 degrees. The values of the electronic energies (-635 to -1145 a.u.), the highest occupied molecular orbital energies (-0.181 to 0.073 a.u.) and lowest unoccupied molecular orbital energies (-0.056 to 0.167 a.u.) indicate the stability of the complexes. The complexes are polarized as indicated from the dipole moment values (9.39-14.27 Debye). The complexes have noticeable cytotoxicity with IC50 (mu M): 0.011-0.062 (HepG-2), 0.015-0.080 (MCF-7), 0.015-0.116 (HCT-116), and PC-3 (0.034-0.125). | URI: | https://doi.org/10.1134/S0036023619060020 https://hdl.handle.net/11147/9611 |
ISSN: | 0036-0236 1531-8613 |
Appears in Collections: | Photonics / Fotonik Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
Files in This Item:
File | Size | Format | |
---|---|---|---|
S0036023619060020.pdf | 1.84 MB | Adobe PDF | View/Open |
CORE Recommender
SCOPUSTM
Citations
2
checked on Sep 1, 2024
WEB OF SCIENCETM
Citations
2
checked on Aug 24, 2024
Page view(s)
438
checked on Sep 2, 2024
Download(s)
586
checked on Sep 2, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.