Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/9616
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dc.contributor.authorKaradaş, Özge-
dc.contributor.authorMeşe, Gülistan-
dc.contributor.authorÖzçivici, Engin-
dc.date.accessioned2020-07-25T22:17:45Z-
dc.date.available2020-07-25T22:17:45Z-
dc.date.issued2019-
dc.identifier.issn0273-2289-
dc.identifier.issn1559-0291-
dc.identifier.issn0273-2289-
dc.identifier.issn1559-0291-
dc.identifier.urihttps://doi.org/10.1007/s12010-018-02934-7-
dc.identifier.urihttps://hdl.handle.net/11147/9616-
dc.descriptionPubMed: 30536030en_US
dc.description.abstractCarnosol and carnosic acid are polyphenolic compounds found in rosemary and sage with known anti-oxidant, anti-inflammatory, and anti-microbial properties. Here, we addressed the potential use of carnosol and carnosic acid for in vitro bone tissue engineering applications, specifically depending on their cytotoxic effects on bone marrow stromal and stem cells, and osteosarcoma cells in monolayer and 3D cultures. Carnosol and carnosic acid displayed a bacteriostatic effect on Gram-positive bacteria, especially on S. aureus. The viability results indicated that bone marrow stromal cells and bone marrow stem cells were more tolerant to the presence of carnosol compared to osteosarcoma cells. 3D culture conditions increased this tolerance further for healthy cells, while not affecting the cytotoxic potential of carnosol for osteosarcoma cells. Carnosic acid was found to be more cytotoxic for all cell types used in the study. Results suggest that phenolic compounds might have potential use as anti-microbial and anti-carcinogenic agents for bone tissue engineering with further optimization for controlled release.en_US
dc.language.isoenen_US
dc.publisherHumana Pressen_US
dc.relation.ispartofApplied Biochemistry and Biotechnologyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCarnosolen_US
dc.subjectCarnosic aciden_US
dc.subjectBone tissue engineeringen_US
dc.subjectFilter paperen_US
dc.subject3D cultureen_US
dc.titleCytotoxic tolerance of healthy and cancerous bone cells to anti-microbial phenolic compounds depend on culture conditionsen_US
dc.typeArticleen_US
dc.institutionauthorKaradaş, Özge-
dc.institutionauthorMeşe, Gülistan-
dc.institutionauthorÖzçivici, Engin-
dc.institutionauthorKaradaş, Özge-
dc.institutionauthorMeşe, Gülistan-
dc.institutionauthorÖzçivici, Engin-
dc.departmentİzmir Institute of Technology. Bioengineeringen_US
dc.departmentİzmir Institute of Technology. Molecular Biology and Geneticsen_US
dc.identifier.volume188en_US
dc.identifier.issue2en_US
dc.identifier.startpage514en_US
dc.identifier.endpage526en_US
dc.identifier.wosWOS:000468165500017en_US
dc.identifier.scopus2-s2.0-85058136823en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s12010-018-02934-7-
dc.identifier.pmid30536030en_US
dc.relation.doi10.1007/s12010-018-02934-7en_US
dc.coverage.doi10.1007/s12010-018-02934-7en_US
dc.identifier.wosqualityQ3-
dc.identifier.scopusqualityQ3-
item.grantfulltextopen-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
crisitem.author.dept03.01. Department of Bioengineering-
Appears in Collections:Bioengineering / Biyomühendislik
Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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