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https://hdl.handle.net/11147/9616
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Karadaş, Özge | - |
dc.contributor.author | Meşe, Gülistan | - |
dc.contributor.author | Özçivici, Engin | - |
dc.date.accessioned | 2020-07-25T22:17:45Z | - |
dc.date.available | 2020-07-25T22:17:45Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0273-2289 | - |
dc.identifier.issn | 1559-0291 | - |
dc.identifier.issn | 0273-2289 | - |
dc.identifier.issn | 1559-0291 | - |
dc.identifier.uri | https://doi.org/10.1007/s12010-018-02934-7 | - |
dc.identifier.uri | https://hdl.handle.net/11147/9616 | - |
dc.description | PubMed: 30536030 | en_US |
dc.description.abstract | Carnosol and carnosic acid are polyphenolic compounds found in rosemary and sage with known anti-oxidant, anti-inflammatory, and anti-microbial properties. Here, we addressed the potential use of carnosol and carnosic acid for in vitro bone tissue engineering applications, specifically depending on their cytotoxic effects on bone marrow stromal and stem cells, and osteosarcoma cells in monolayer and 3D cultures. Carnosol and carnosic acid displayed a bacteriostatic effect on Gram-positive bacteria, especially on S. aureus. The viability results indicated that bone marrow stromal cells and bone marrow stem cells were more tolerant to the presence of carnosol compared to osteosarcoma cells. 3D culture conditions increased this tolerance further for healthy cells, while not affecting the cytotoxic potential of carnosol for osteosarcoma cells. Carnosic acid was found to be more cytotoxic for all cell types used in the study. Results suggest that phenolic compounds might have potential use as anti-microbial and anti-carcinogenic agents for bone tissue engineering with further optimization for controlled release. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Humana Press | en_US |
dc.relation.ispartof | Applied Biochemistry and Biotechnology | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Carnosol | en_US |
dc.subject | Carnosic acid | en_US |
dc.subject | Bone tissue engineering | en_US |
dc.subject | Filter paper | en_US |
dc.subject | 3D culture | en_US |
dc.title | Cytotoxic tolerance of healthy and cancerous bone cells to anti-microbial phenolic compounds depend on culture conditions | en_US |
dc.type | Article | en_US |
dc.institutionauthor | Karadaş, Özge | - |
dc.institutionauthor | Meşe, Gülistan | - |
dc.institutionauthor | Özçivici, Engin | - |
dc.institutionauthor | Karadaş, Özge | - |
dc.institutionauthor | Meşe, Gülistan | - |
dc.institutionauthor | Özçivici, Engin | - |
dc.department | İzmir Institute of Technology. Bioengineering | en_US |
dc.department | İzmir Institute of Technology. Molecular Biology and Genetics | en_US |
dc.identifier.volume | 188 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 514 | en_US |
dc.identifier.endpage | 526 | en_US |
dc.identifier.wos | WOS:000468165500017 | en_US |
dc.identifier.scopus | 2-s2.0-85058136823 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1007/s12010-018-02934-7 | - |
dc.identifier.pmid | 30536030 | en_US |
dc.relation.doi | 10.1007/s12010-018-02934-7 | en_US |
dc.coverage.doi | 10.1007/s12010-018-02934-7 | en_US |
dc.identifier.wosquality | Q3 | - |
dc.identifier.scopusquality | Q3 | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 04.03. Department of Molecular Biology and Genetics | - |
crisitem.author.dept | 03.01. Department of Bioengineering | - |
Appears in Collections: | Bioengineering / Biyomühendislik Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
Files in This Item:
File | Description | Size | Format | |
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Karadas2019_Article.pdf | Makale (Article) | 1.34 MB | Adobe PDF | View/Open |
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