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Title: Therapeutic Potentials of Inhibition of Jumonji C Domain-containing Demethylases in Acute Myeloid Leukemia
Authors: Koca, Duygu
Hastar, Nurcan
Engür, Selin
Kiraz, Yağmur
Ulu, Gizem Tuğçe
Çekdemir, Demet
Baran, Yusuf
Moleküler Biyoloji ve Genetik Bölümü
Moleküler Biyoloji ve Genetik Bölümü
Anadolu Üniversitesi
Moleküler Biyoloji ve Genetik Bölümü
Moleküler Biyoloji ve Genetik Bölümü
Sakarya Üniversitesi
Moleküler Biyoloji ve Genetik Bölümü
Keywords: Acute myeloid leukemia
Jumonji C domain
Histone methylation
Issue Date: 2020
Publisher: Aves
Abstract: Acute myeloid leukemia (AML) is a complex disease affected by both genetic and epigenetic factors. Histone methylation and demethylation are types of epigenetic modification in chromatin remodeling and gene expression. Abnormal expression of histone demethylases is indicated in many types of cancer including AML. Although many commercial drugs are available to treat AML, an absolute cure has not been discovered yet. However, inhibition of demethylases could be a potential cure for AML. Methylstat is a chemical agent that inhibits the Jumonji C domain-containing demethylases.
ISSN: 13007777
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
TR Dizin İndeksli Yayınlar / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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