Synthesis of Α,β-Unsaturated Ketones by Rhodium-Catalyzed Carbonylative Arylation of Internal Alkynes With Arylboronic Acids

Kuş, MelihAksın Artok, ÖzgeZiyanak, FıratArtok, Levent2016-10-312016-10-312008Kuş, M., Aksın Artok, Ö., Ziyanak, F., and Artok, L. (2008). Synthesis of α,β-unsaturated ketones by rhodium-catalyzed carbonylative arylation of internal alkynes with arylboronic acids. Synlett, (17), 2587-2592.0936-5214https://hdl.handle.net/11147/2354http://doi.org/10.1055/s-2008-1078047The Rh-catalyzed reaction of arylboronic acids with internal alkynes under a CO atmosphere in the presence of an acid additive afforded α,β-unsaturated ketones as the major products. Hydroacylation of internal alkynes, except in the case of diaryl acetylenes, proceeded in syn fashion, yielding the E-configured isomer. A mixture of E- and Z-isomers was obtained with diphenyl acetylene. Reactions were also highly regioselective for various nonsymmetric alkynes.eninfo:eu-repo/semantics/openAccessAlkynesBoronCarbonylationEnonesRhodiumSynthesis of Α,β-Unsaturated Ketones by Rhodium-Catalyzed Carbonylative Arylation of Internal Alkynes With Arylboronic AcidsArticle2-s2.0-5554910840210.1055/s-2008-107804710.1055/s-2008-107804710.1055/s-2008-1078047