Karabıyık, M.Cihanoğlu, G.Ebil, Ö.2026-02-252026-02-2520260009-2509https://doi.org/10.1016/j.ces.2026.123554https://hdl.handle.net/11147/18962Semiconductor quantum dots (QDs) are attractive fluorophores for sensor applications due to their narrow emission bandwidths and high photostability; however, their performance is often limited by insufficient chemical and thermal durability under operating conditions. In this study, a solvent-free encapsulation strategy based on initiated chemical vapor deposition (iCVD) is proposed to enhance the stability of QD-based sensor nanoprobes. Cross-linked poly (glycidyl methacrylate-co-ethylene glycol dimethacrylate) (ECOP) thin films were conformally deposited as encapsulation layers onto CdTe QD-functionalized poly(GMA) sensor surfaces. The encapsulated nanoprobes were evaluated under chemically aggressive environments (water, salt water, toluene, and sulfuric acid) and elevated temperatures. Following exposure to aggressive solvents, both the polymer film thickness variation and QD fluorescence intensity change remained below 10 %, confirming the robustness of the cross-linked network. Also, thermal durability tests showed stable fluorescence performance after annealing at 250 °C, with structural and optical changes remaining within the accepted 10 % threshold. The results demonstrate that coatings deposited using iCVD exhibit conformal coverage and enhanced stability. This enables reliable protection of QD-based sensor nanoprobes without compromising optical performance. This study presents a promising method to extend the operational lifetime and environmental durability of QD-integrated sensor platforms by using chemically and thermally stable polymer encapsulation. © 2026 Elsevier Ltdeninfo:eu-repo/semantics/closedAccessCross-Linked Copolymer Thin FilmEncapsulationInitiated Chemical Vapor Deposition (ICVD)Protective CoatingQuantum Dots (QDs)Sensor NanoprobeArticle2-s2.0-10502960140210.1016/j.ces.2026.123554