Seyrantepe, Volkan2023-10-032023-10-0320231096-71921096-7206https://doi.org/10.1016/j.ymgme.2022.107315https://hdl.handle.net/11147/1377219th Annual WORLD Symposium 22-26 February 2023Tay-Sachs disease is a neurodegenerative lysosomal storage disorder caused by mutations in the Hexa gene, which encodes the alpha subunit of lysosomal ß-hexaminidase A (HEXA). HEXA is responsible for the conversion of GM2 to GM3, therefore the deficiency leads to the accumulation of GM2 in the lysosomes, neurodegeneration, and eventual death. Currently, there is no efficient therapy for the disease yet.eninfo:eu-repo/semantics/closedAccessConference Object10.1016/j.ymgme.2022.107315