Mazare, AncaGoldmann, Wolfgang HeinrichKocak, EsraOsuagwu, BenedictQin, ShanshanCao, RanSchmuki, Patrik2025-08-272025-08-2720251530-69841530-6992https://doi.org/10.1021/acs.nanolett.5c02681Conventional Ag-decorated TiO<inf>2</inf>coatings suffer from low adsorption capacity and burst release kinetics, limiting long-term antibacterial efficacy and risking cytotoxicity. An entirely different payload release approach can be based on metal–organic frameworks (MOFs), which offer tunable porosity, high surface area, and internal diffusion channels. Here, we report a thermally stabilized Ti-based MOF [NH<inf>2</inf>-MIL-125(Ti)] functionalized with Ag+via reactive deposition, enabling high Ag loading (∼14.7 wt %) and sustained release. Annealing at 250 °C enhances aqueous stability, allowing diffusion-governed Ag+delivery over >48 h, with 77% of the Ag still present in the MOF after a 24 h release. The system exhibits dose-dependent antibacterial activity in powders and comparable efficacy in coatings, with a more gradual release profile. This scalable platform is promising for long-acting coatings, wound interfaces, and implantable materials. © 2025 Elsevier B.V., All rights reserved.eninfo:eu-repo/semantics/closedAccessAntibacterial ActivityMetal–Organic Frameworks (MOFs)NH2-MIL-125SilverSilverTitaniumTitanium DioxideAnti-Bacterial AgentsMetal-Organic FrameworksSilverTitaniumTitanium DioxideCrystalline MaterialsDiffusion CoatingsInterfaces (Materials)Metal IonsOrganometallicsSilver CompoundsTitanium DioxideAdsorption CapacitiesAg +Anti-Bacterial ActivityAntibacterialsMetalorganic Frameworks (Mofs)Metal−Organic-FrameworkNH2-MIL-125Silver Ion ReleaseTiO₂Titanium-BasedSilverAntiinfective AgentMetal Organic FrameworkSilverTitaniumTitanium DioxideChemistryDrug EffectDrug ReleaseEscherichia ColiMicrobial Sensitivity TestPorosityStaphylococcus AureusAnti-Bacterial AgentsDrug LiberationMetal-Organic FrameworksMicrobial Sensitivity TestsPorosityTitaniumArticle2-s2.0-10501380878710.1021/acs.nanolett.5c02681