Please use this identifier to cite or link to this item:
Title: Therapeutic potential of fisetin, vitexin and hesperetin on chronic myeloid leukemia cells
Authors: Adan Gökbulut, Aysun
Baran, Yusuf
Issue Date: 2014
Publisher: Elsevier Ltd.
Abstract: In Chronic Myeloid Leukemia (CML) treatment, despite therapeutic efficacy of tyrosine kinase inhibitors, resistance development and side effects cause problems. Fisetin, vitexin and hesperetin are plant-derived flavonoids. In this study, therapeutic potentials of fisetin, vitexin and hesperetin were determined in CML cells. Cytotoxic effects of flavonoids were determined by MTT assay while apoptotic effects were determined by changes in caspase- 3 activity, loss of mitochondrial membrane potential (MMP) and Annexin V/PI double staining. Cytostatic effects of the flavonoids were evaluated by propidium iodide staining using flow cytometry.
Description: 5th International Eurasian Hematology Congress
ISSN: 0145-2126
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Files in This Item:
File SizeFormat 
1-s2.0-S0145212614701225-main.pdf75.89 kBAdobe PDFView/Open
Show full item record

CORE Recommender

Page view(s)

checked on Nov 27, 2023


checked on Nov 27, 2023

Google ScholarTM



Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.