Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/11260
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dc.contributor.authorSoran, Atilla-
dc.contributor.authorÖzmen, Vahit-
dc.contributor.authorÖzbaş, Serdar-
dc.contributor.authorKaranlık, Hasan-
dc.contributor.authorMüslümanoğlu, Mahmut-
dc.contributor.authorİğci, Abdullah-
dc.contributor.authorCantürk, Nuh Zafer-
dc.contributor.authorUtkan, Zafer-
dc.contributor.authorEvrensel, Türkkan-
dc.contributor.authorSezgin, Efe-
dc.date.accessioned2021-11-06T09:27:13Z-
dc.date.available2021-11-06T09:27:13Z-
dc.date.issued2021-
dc.identifier.issn1072-7515-
dc.identifier.urihttp://doi.org/10.1016/j.jamcollsurg.2021.08.686-
dc.identifier.urihttps://hdl.handle.net/11147/11260-
dc.description.abstractBackground: The aim of this randomized clinical trial was to evaluate the overall survival (OS) data of patients diagnosed with de novo stage IV breast cancer (BC) who received locoregional treatment (LRT) over a 10-year follow-up. Study Design: The MF07-01 is a 1:1 multicenter, randomized clinical trial comparing the LRT with systemic therapy (ST), where ST was given to all patients either immediately after randomization or after surgical resection of the intact primary tumor. Results: A total of 278 patients were randomized and 265 patients were in the final analysis. At 10-year follow-up, survivals were 19% (95% CI 13%–28%) and 5% (95% CI 2%–12%) in the LRT group and ST group, respectively. Median survival was 46 months for the LRT group and 35 months for the ST group, and hazard of death was 29% lower in the LRT group compared with the ST group (hazard ratio [HR] 0.71; 95% CI 0.59–0.86; p = 0.0003). Conclusions: Patients with a diagnosis of de novo stage IV BC who underwent LRT followed by ST had a 14% higher chance of OS by the end of the 10-year follow-up compared with the patients who received only ST. The longer study follow-up revealed that LRT should be presented to patients when discussing treatment options. © 2021 American College of Surgeonsen_US
dc.description.sponsorshipThanks to Christine Burr, Scientific Writer, from the University of Pittsburgh, for her assistance with language editing, and as well as Umit Ugurlu, MD, from Marmara University, Betul Bozkurt, MD, from Hitit University, Ali Uzunkoy, MD, from Harran University, Neset Koksal, MD, from Yeditepe University, Bulent Unal, MD, from Osmangazi University, Can Atalay, MD, from VKV Amerikan Hospital Istanbul, Semra Salimoglu, MD, from Izmir SBU Tepecik Teaching and Research Hospital, Atakan Sezer, MD, from Trakya University, Ayhan Koyuncu, MD, from Medicana Sivas Hospital, Gunay Gurleyik, MD, from Haydarpasa Numune Teaching and Research Hospital, Nalan Ulufi, MD, from Medical Park Pendik Hospital, Omer Cengiz, MD, from Koru Ankara Hospital, Mustafa Dulger, MD, from Kocaeli Cihan Hospital, and Ugur Berberoglu, MD, Emin Yildirim, MD, Haluk Alagol, MD, and Temel Dagoglu, MD for patient recruitment. We also thank Ronald Johnson, MD, FACS, Department of Surgery, UPMC Magee-Womens Hospital, Pittsburgh, PA, for his guidance and contributions during the data analysis.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of the American College of Surgeonsen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBreast canceren_US
dc.titlePrimary surgery with systemic therapy in patients with de novo stage IV breast cancer: 10-year follow-up; protocol MF07-01 randomized clinical trialen_US
dc.typeConference Objecten_US
dc.institutionauthorSezgin, Efe-
dc.departmentİzmir Institute of Technology. Food Engineeringen_US
dc.identifier.wosWOS:000721601000012en_US
dc.identifier.scopus2-s2.0-85117208557en_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.jamcollsurg.2021.08.686-
dc.identifier.pmid34530124en_US
dc.identifier.wosqualityQ1-
dc.identifier.scopusqualityQ1-
dc.identifier.wosqualityttpTop10%en_US
item.openairetypeConference Object-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextopen-
crisitem.author.dept03.08. Department of Food Engineering-
Appears in Collections:Food Engineering / Gıda Mühendisliği
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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