Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/11558
Title: Four subtypes of childhood allergic rhinitis identified by latent class analysis
Authors: Yavuz, Süleyman Tolga
Öksel Karakuş, Ceyda
Custovic, Adnan
Kalaycı, Ömer
Keywords: Allergic rhinitis
Allergy
Asthma
Children
Phenotype
Issue Date: 2021
Publisher: Wiley
Abstract: Background Childhood allergic rhinitis (AR) is clinically heterogenous. We aimed to identify distinct phenotypes among children with AR using data-driven techniques and to ascertain their association with patterns of symptoms, allergic sensitization, and comorbidities. Methods We recruited 510 children with physician-diagnosed AR, of whom 205 (40%) had asthma. Latent class analysis (LCA) was performed to identify latent structure within the data set using 17 variables (allergic conjunctivitis, eczema, asthma, family history of asthma, family history of allergic rhinitis, skin sensitization to 8 common allergens, tonsillectomy, adenoidectomy). Results A four-class solution was selected as the optimal model based on statistical fit. We labeled latent classes as: (1) AR with grass mono-sensitization and conjunctivitis (n = 361, 70.8%); (2) AR with house dust mite sensitization and asthma (n = 75, 14.7%); (3) AR with pet and grass polysensitization and conjunctivitis (n = 35, 6.9%); and (4) AR among children with tonsils and adenoids removed (n = 39, 7.6%). Perennial AR was significantly more common among children in Class 2 (OR 5.83, 95% CI 3.42-9.94, p < .001) and Class 3 (OR 2.88, 95% CI 1.36-6.13, p = .006). Mild and intermittent AR symptoms were significantly more common in children in Class 2 compared to those in Class 1. AR was more severe in Class 1 compared to other 3 classes, indicating that upper respiratory symptoms are more severe among children with isolated seasonal rhinitis, than in those with rhinitis and coexisting asthma. Conclusion We have identified 4 phenotypes in school-age children with AR, which were associated with different patterns of clinical symptoms and comorbidities.
URI: https://doi.org/10.1111/pai.13605
https://hdl.handle.net/11147/11558
ISSN: 0905-6157
1399-3038
Appears in Collections:Bioengineering / Biyomühendislik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Files in This Item:
File SizeFormat 
Pediatric Allergy Immunology.pdf515.18 kBAdobe PDFView/Open
Show full item record



CORE Recommender

SCOPUSTM   
Citations

8
checked on Feb 16, 2024

WEB OF SCIENCETM
Citations

7
checked on Feb 17, 2024

Page view(s)

62
checked on Feb 19, 2024

Download(s)

20
checked on Feb 19, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.