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Title: Current status and perspectives of protease inhibitors and their combination with nanosized drug delivery systems for targeted cancer therapy
Authors: Rudzinska, Magdalena
Dağlıoğlu, Cenk
Savvateeva, Lyudmila, V
Kaci, Fatma Necmiye
Antoine, Rodolphe
Zamyatnin, Andrey A., Jr.
Keywords: Proteases
Nanoscale drug-delivery system
Combination therapy
Cancer treatment
Issue Date: 2021
Publisher: Dove Medical Press Ltd
Abstract: In cancer treatments, many natural and synthetic products have been examined; among them, protease inhibitors are promising candidates for anti-cancer agents. Since dysregulated proteolytic activities can contribute to tumor development and metastasis, antagonization of proteases with tailored inhibitors is an encouraging approach. Although adverse effects of early designs of these inhibitors disappeared after the introduction of next-generation agents, most of the proposed inhibitors did not pass the early stages of clinical trials due to their nonspecific toxicity and lack of pharmacological effects. Therefore, new applications that modulate proteases more specifically and serve their programmed way of administration are highly appreciated. In this context, nanosized drug delivery systems have attracted much attention because preliminary studies have demonstrated that the therapeutic capacity of inhibitors has been improved significantly with encapsulated formulation as compared to their free forms. Here, we address this issue and discuss the current application and future clinical prospects of this potential combination towards targeted protease-based cancer therapy.
ISSN: 1177-8881
Appears in Collections:IZTECH Research Centers Collection / İYTE Araştırma Merkezleri Koleksiyonu
Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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