Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/12676
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dc.contributor.authorZeybek, Nükettr
dc.contributor.authorBüyükkileci, Ali Oğuztr
dc.contributor.authorGüleç, Şükrütr
dc.contributor.authorPolat, Mehmettr
dc.contributor.authorPolat, Hürriyettr
dc.date.accessioned2022-12-19T08:44:48Z-
dc.date.available2022-12-19T08:44:48Z-
dc.date.issued2023-01-
dc.identifier.urihttps://doi.org/10.1016/j.jddst.2022.103983-
dc.identifier.urihttps://hdl.handle.net/11147/12676-
dc.description.abstractong residence times, near-neutral pH values, and release triggered by the enzymatic action of the resident microbiota offer unique opportunities for improved drug delivery in the colon. The fact that a delivery agent must also pass through the complete GI tract without degradation presents a challenge due to widely changing pH conditions. In this study, a promising colon-targeted drug delivery system was composed of a xylan/chitosan composite shell formed on curcumin-loaded mesoporous silica nanoparticles (MSNs). A novel synthesis approach was employed to facilitate precipitation of negatively charged xylan on negatively charged MSNs by concurrent chitosan polymerization. Curcumin-loaded xylan/chitosan-coated MSNs (C-MSNs) were determined to contain nearly 42% xylan by the inclusion of chitosan in a one-to-one ratio with xylan. The xylan/chitosan composite shell demonstrated excellent stability in the acidic upper GI tract. The hydrolysis of glycosidic bonds by resident microbiota was the triggering mechanism for xylan degradation and curcumin release in the colon. The presence of xylan has the further benefit of increasing the number of beneficial bacteria and improving short-chain fatty acid production for improved colon health.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Drug Delivery Science and Technologyen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectBacterial degradationen_US
dc.subjectColon-targeted drug deliveryen_US
dc.subjectChitosanen_US
dc.subjectMesoporous silica nanoparticles (MSNs)en_US
dc.subjectXylanen_US
dc.titleDesigning robust xylan/chitosan composite shells around drug-loaded MSNs: Stability in upper GIT and degradation in the colon microbiotaen_US
dc.typeArticleen_US
dc.authorid0000-0003-4416-6822en_US
dc.authorid0000-0002-0784-0008en_US
dc.authorid0000-0002-6789-1050en_US
dc.authorid0000-0002-1573-0351en_US
dc.departmentİzmir Institute of Technology. Chemical Engineeringen_US
dc.departmentİzmir Institute of Technology. Food Engineeringen_US
dc.departmentİzmir Institute of Technology. Bioengineeringen_US
dc.identifier.wosWOS:000897270000004en_US
dc.identifier.scopus2-s2.0-85143334938en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1016/j.jddst.2022.103983-
dc.relation.issn1773-2247en_US
dc.description.volume79en_US
dc.identifier.scopusqualityQ1-
item.fulltextWith Fulltext-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextembargo_20250101-
item.languageiso639-1en-
crisitem.author.dept03.08. Department of Food Engineering-
crisitem.author.dept03.08. Department of Food Engineering-
crisitem.author.dept03.02. Department of Chemical Engineering-
crisitem.author.dept04.01. Department of Chemistry-
Appears in Collections:Bioengineering / Biyomühendislik
Chemical Engineering / Kimya Mühendisliği
Food Engineering / Gıda Mühendisliği
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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