Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/13819
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dc.contributor.authorBal, Yıldız-
dc.contributor.authorSürmeli, Yusuf-
dc.contributor.authorŞanlı Mohamed, Gülşah-
dc.date.accessioned2023-10-03T07:16:27Z-
dc.date.available2023-10-03T07:16:27Z-
dc.date.issued2023-
dc.identifier.issn2470-1343-
dc.identifier.urihttps://doi.org/10.1021/acsomega.3c01493-
dc.identifier.urihttps://hdl.handle.net/11147/13819-
dc.description.abstractAlginate microcapsules are a talented means for the delivery of broad curative biomacromolecules. In this study, we immobilized olive leaf extract (OLE) by calcium alginate (CA) and chitosan-coated CA (CCA) and characterized the OLE-loaded CA and CCA. The cytotoxic effect, the cell cycle arrest, and the apoptotic effect of OLE and its microcapsules were investigated against breast adenocarcinoma (MCF-7) and lung carcinoma (A549). As a result, the loading capacity of OLE-CA and OLE-CCA was found to be 80 and 99%, respectively, in optimal conditions. Also, OLE-CA and OLE-CCA were characterized by unique FTIR peaks and morphological display relative to the empty CCA microcapsules. The cytotoxicity analysis showed that the IC50 values of OLE-CA and OLE-CCA were determined to be 312 and 0.94 μg mL-1 against A549, respectively, whereas these were found to be 865.4 and 425.5 μg mL-1 for MCF-7 cells. On the other hand, the OLE microcapsules did not possess in any concentration of cytotoxic influence on the BEAS 2B healthy cell line. Also, the exposure of OLE-CCA to MCF-7 and A549 resulted in the arrest of more MCF-7 and A549 cells at the G0/G1 phase compared to the OLE. A549 and MCF-7 cells were predominantly found in the late apoptosis phase and necrosis phase, respectively. Optical microscopy images confirmed that OLE microcapsules were more effective against MCF-7 and A549 than free OLE. The present work suggested that the OLE microcapsules might be administered as nutrition supplements for cancer therapy. © 2023 The Authors. Published by American Chemical Society.en_US
dc.description.sponsorshipThe authors would like to thank the Biotechnology & Bioengineering Research Center at the İzmir Institute of Technology for the facilities and technical support.en_US
dc.language.isoenen_US
dc.publisherAmerican Chemical Societyen_US
dc.relation.ispartofACS Omegaen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOlive leaf extracten_US
dc.subjectAlginate microcapsulesen_US
dc.subjectOleuropeinen_US
dc.titleAntiproliferative and apoptotic effects of olive leaf extract microcapsules on MCF-7 and A549 cancer cellsen_US
dc.typeArticleen_US
dc.authorid0000-0002-9645-6314-
dc.authorid0000-0003-0282-4428-
dc.departmentİzmir Institute of Technology. Chemistryen_US
dc.departmentİzmir Institute of Technology. Bioengineeringen_US
dc.identifier.volume8en_US
dc.identifier.issue32en_US
dc.identifier.startpage28984en_US
dc.identifier.endpage28993en_US
dc.identifier.wosWOS:001041106400001en_US
dc.identifier.scopus2-s2.0-85167883055en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1021/acsomega.3c01493-
dc.identifier.pmid37599941-
dc.authorscopusid57193096604-
dc.authorscopusid55758999000-
dc.authorscopusid36680469600-
dc.identifier.scopusqualityQ1-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
item.openairetypeArticle-
crisitem.author.dept04.01. Department of Chemistry-
Appears in Collections:Bioengineering / Biyomühendislik
Chemistry / Kimya
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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