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https://hdl.handle.net/11147/13819
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bal, Yıldız | - |
dc.contributor.author | Sürmeli, Yusuf | - |
dc.contributor.author | Şanlı Mohamed, Gülşah | - |
dc.date.accessioned | 2023-10-03T07:16:27Z | - |
dc.date.available | 2023-10-03T07:16:27Z | - |
dc.date.issued | 2023 | - |
dc.identifier.issn | 2470-1343 | - |
dc.identifier.uri | https://doi.org/10.1021/acsomega.3c01493 | - |
dc.identifier.uri | https://hdl.handle.net/11147/13819 | - |
dc.description.abstract | Alginate microcapsules are a talented means for the delivery of broad curative biomacromolecules. In this study, we immobilized olive leaf extract (OLE) by calcium alginate (CA) and chitosan-coated CA (CCA) and characterized the OLE-loaded CA and CCA. The cytotoxic effect, the cell cycle arrest, and the apoptotic effect of OLE and its microcapsules were investigated against breast adenocarcinoma (MCF-7) and lung carcinoma (A549). As a result, the loading capacity of OLE-CA and OLE-CCA was found to be 80 and 99%, respectively, in optimal conditions. Also, OLE-CA and OLE-CCA were characterized by unique FTIR peaks and morphological display relative to the empty CCA microcapsules. The cytotoxicity analysis showed that the IC50 values of OLE-CA and OLE-CCA were determined to be 312 and 0.94 μg mL-1 against A549, respectively, whereas these were found to be 865.4 and 425.5 μg mL-1 for MCF-7 cells. On the other hand, the OLE microcapsules did not possess in any concentration of cytotoxic influence on the BEAS 2B healthy cell line. Also, the exposure of OLE-CCA to MCF-7 and A549 resulted in the arrest of more MCF-7 and A549 cells at the G0/G1 phase compared to the OLE. A549 and MCF-7 cells were predominantly found in the late apoptosis phase and necrosis phase, respectively. Optical microscopy images confirmed that OLE microcapsules were more effective against MCF-7 and A549 than free OLE. The present work suggested that the OLE microcapsules might be administered as nutrition supplements for cancer therapy. © 2023 The Authors. Published by American Chemical Society. | en_US |
dc.description.sponsorship | The authors would like to thank the Biotechnology & Bioengineering Research Center at the İzmir Institute of Technology for the facilities and technical support. | en_US |
dc.language.iso | en | en_US |
dc.publisher | American Chemical Society | en_US |
dc.relation.ispartof | ACS Omega | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Olive leaf extract | en_US |
dc.subject | Alginate microcapsules | en_US |
dc.subject | Oleuropein | en_US |
dc.title | Antiproliferative and apoptotic effects of olive leaf extract microcapsules on MCF-7 and A549 cancer cells | en_US |
dc.type | Article | en_US |
dc.authorid | 0000-0002-9645-6314 | - |
dc.authorid | 0000-0003-0282-4428 | - |
dc.department | İzmir Institute of Technology. Chemistry | en_US |
dc.department | İzmir Institute of Technology. Bioengineering | en_US |
dc.identifier.volume | 8 | en_US |
dc.identifier.issue | 32 | en_US |
dc.identifier.startpage | 28984 | en_US |
dc.identifier.endpage | 28993 | en_US |
dc.identifier.wos | WOS:001041106400001 | en_US |
dc.identifier.scopus | 2-s2.0-85167883055 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.doi | 10.1021/acsomega.3c01493 | - |
dc.identifier.pmid | 37599941 | - |
dc.authorscopusid | 57193096604 | - |
dc.authorscopusid | 55758999000 | - |
dc.authorscopusid | 36680469600 | - |
dc.identifier.wosquality | Q2 | - |
dc.identifier.scopusquality | Q2 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.openairetype | Article | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
crisitem.author.dept | 04.01. Department of Chemistry | - |
Appears in Collections: | Bioengineering / Biyomühendislik Chemistry / Kimya PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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File | Size | Format | |
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Antiproliferative.pdf | 7.76 MB | Adobe PDF | View/Open |
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