Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/14371
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dc.contributor.authorInci, Orhan Kerim-
dc.contributor.authorBasirli, Hande-
dc.contributor.authorCan, Melike-
dc.contributor.authorYanbul, Selman-
dc.contributor.authorSeyrantepe, Volkan-
dc.date.accessioned2024-05-05T14:57:05Z-
dc.date.available2024-05-05T14:57:05Z-
dc.date.issued2024-
dc.identifier.issn2090-3030-
dc.identifier.issn2090-3049-
dc.identifier.urihttps://doi.org/10.1155/2024/4530255-
dc.identifier.urihttps://hdl.handle.net/11147/14371-
dc.description.abstractGangliosides, sialic acid-containing glycosphingolipids, are abundant in cell membranes and primarily involved in controlling cell signaling and cell communication. The altered ganglioside pattern has been demonstrated in several neurodegenerative diseases, characterized during early-onset or infancy, emphasizing the significance of gangliosides in the brain. Enzymes required for the biosynthesis of gangliosides are linked to several devastating neurological disorders, including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), hereditary spastic paraplegia (HSP). In this review, we summarized not only the critical roles of biosynthetic enzymes and their inhibitors in ganglioside metabolism but also the efficacy of treatment strategies of ganglioside to address their significance in those diseases.en_US
dc.description.sponsorshipTrkiye Bilimsel ve Teknolojik Arascedil;tirma Kurumu [218S824, 120N552]; Scientific and Technological Research Council of Turkey (TUBITAK)en_US
dc.description.sponsorshipThis study was partially funded by the Scientific and Technological Research Council of Turkey (TUBITAK) (Grants 218S824 and 120N552).en_US
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keyword Available]en_US
dc.titleGangliosides as Therapeutic Targets for Neurodegenerative Diseasesen_US
dc.typeReviewen_US
dc.departmentIzmir Institute of Technologyen_US
dc.identifier.volume2024en_US
dc.identifier.wosWOS:001205917200001-
dc.relation.publicationcategoryDiğeren_US
dc.identifier.doi10.1155/2024/4530255-
dc.identifier.pmid38623278-
dc.identifier.scopusqualityN/A-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeReview-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
crisitem.author.dept04.03. Department of Molecular Biology and Genetics-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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