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Title: | Quercetin-induced apoptosis involves increased hTERT enzyme activity of leukemic cells | Authors: | Avcı, Çığır Biray Yılmaz, Sunde Doğan, Zeynep Özlem Saydam, Güray Dodurga, Yavuz Ekiz, Hüseyin Atakan Kartal, Melis Şahin, Fahri Baran, Yusuf Gündüz, Cumhur |
Keywords: | Apoptosis hTERT Leukemia Quercetin Telomerase |
Publisher: | Taylor and Francis Ltd. | Source: | Avcı, Ç. B., Yılmaz, S., Doğan, Z.Ö., Saydam, G., Dodurga, Y., Ekiz, H. A., Kartal, M., Şahin, F., Baran, Y., and Gündüz, C. (2011). Quercetin-induced apoptosis involves increased hTERT enzyme activity of leukemic cells. Hematology, 16(6) , 303-307. doi:10.1179/102453311X13085644680104 | Abstract: | We aimed to examine the growth suppressive effects of quercetin on acute promyelocytic and lymphoblastic leukemia and chronic myeloid leukemia, and to find out whether the growth suppression is related to the blocking of telomerase enzyme activity. Cytotoxic effects of quercetin were shown by trypan blue analyses. Apoptotic effects of quercetin were examined by acridine orange and ethidium bromide staining by fluorescence microscopy. The effects of quercetin on telomerase enzyme activity were shown by hTERT Quantification Kit. Our results demonstrated that quercetin has antiproliferative and apoptotic effects on T-cell acute lymphoblastic leukemia (ALL), acute promyelocytic leukemia, and chronic myeloid leukemia (CML) cells. We also showed for the first time by this study that quercetin suppresses the activity of telomerase in ALL and CML cells. The results of this study show the importance of quercetin for its therapeutic potential in treatment of leukemias. | URI: | http://doi.org/10.1179/102453311X13085644680104 http://hdl.handle.net/11147/4950 |
ISSN: | 1024-5332 1024-5332 |
Appears in Collections: | Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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