Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5530
Title: Characterization of a cDNA from Beta maritima that confers nickel tolerance in yeast
Authors: Bozdağ, Gönensin Ozan
Kaya, Alaattin
Koç, Ahmet
Noll, Gundula A.
Prüfer, Dirk
Karakaya, Hüseyin Çağlar
Bozdağ, Gönensin Ozan
Kaya, Alaattin
Koç, Ahmet
Karakaya, Hüseyin Çağlar
Keywords: Beta maritima
Heavy metal toxicity
Ion homeostasis
Nickel
Transporter protein
Yeast
Issue Date: Apr-2014
Publisher: Elsevier Ltd.
Source: Bozdağ, G.O., Kaya, A., Koç, A., Noll, G.A., Prüfer, D., and Karakaya, H.Ç. (2014). Characterization of a cDNA from Beta maritima that confers nickel tolerance in yeast. Gene, 538(2), 251-257. doi:10.1016/j.gene.2014.01.052
Abstract: Nickel is an essential micronutrient due to its involvement in many enzymatic reactions as a cofactor. However, excess of this element is toxic to biological systems. Here, we constructed a cDNA library from Beta maritima and screened it in the yeast system to identify genes that confer resistance to toxic levels of nickel. A cDNA clone (NIC6), which encodes for a putative membrane protein with unknown function, was found to help yeast cells to tolerate toxic levels of nickel. A GFP fused form of Nic6 protein was localized to multivesicular structures in tobacco epidermal cells. Thus, our results suggest a possible role of Nic6 in nickel and intracellular ion homeostasis.
URI: https://doi.org/10.1016/j.gene.2014.01.052
http://hdl.handle.net/11147/5530
ISSN: 0378-1119
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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