Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5547
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dc.contributor.authorŞamlı, Merve-
dc.contributor.authorBayraktar, Oğuz-
dc.contributor.authorKorel, Figen-
dc.date.accessioned2017-05-18T06:48:56Z-
dc.date.available2017-05-18T06:48:56Z-
dc.date.issued2014-10-
dc.identifier.citationŞamlı, M., Bayraktar, O., and Korel, F. (2014). Characterization of silk fibroin based films loaded with rutin-β-cyclodextrin inclusion complexes. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 80(1-2), 37-49. doi:10.1007/s10847-014-0396-4en_US
dc.identifier.issn1573-1111-
dc.identifier.issn1388-3127-
dc.identifier.urihttp://doi.org/10.1007/s10847-014-0396-4-
dc.identifier.urihttp://hdl.handle.net/11147/5547-
dc.description.abstractIn this study, cyclodextrin inclusion complexes with rutin were prepared via co-precipitation method. Stability constant and solubility energy of beta-cyclodextrin complex were calculated as 262 M-1 and 1,737 kJ mol-1, respectively. Aqueous solubility of rutin was increased with inclusion complex of beta-cyclodextrin. The effect of temperature on both aqueous solubility of free rutin, and its inclusion complex was also studied. Characterization of cyclodextrin complexes were conducted with UV-Vis spectrophotometry, Fourier transform infrared spectroscopy, X-ray diffractometry, differential scanning calorimetry, thermal gravimetric analysis, nuclear magnetic resonance spectroscopy and scanning electron microscopy techniques. Characterization results supported formation of inclusion complexes. Dissolution profiles of rutin, physical mixture and inclusion complex of rutin were observed at 37 °C. Dissolution results proved the effect of cyclodextrin addition on solubility rate of rutin. After loading rutin and its complexes into silk fibroin based films, release tests were performed at 37 °C in neutral pH conditions for 24 h. Most of the rutin were released from silk fibroin films within the first 5 h and the rest of it was released slowly (sustained release). Electron microscope analyses showed that films had homogenous and dense morphologies. These results revealed that silk fibroin is useful for preparing bioactive films loaded with natural compounds and for modifying their release behaviour at physiological conditions.en_US
dc.language.isoenen_US
dc.publisherKluwer Academic Publishersen_US
dc.relation.ispartofJournal of Inclusion Phenomena and Macrocyclic Chemistryen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBeta-cyclodextrinen_US
dc.subjectInclusion complexen_US
dc.subjectSilk fibroin filmen_US
dc.subjectRutinen_US
dc.titleCharacterization of silk fibroin based films loaded with rutin-ß-cyclodextrin inclusion complexesen_US
dc.typeArticleen_US
dc.authoridTR110179en_US
dc.institutionauthorŞamlı, Merve-
dc.institutionauthorBayraktar, Oğuz-
dc.institutionauthorKorel, Figen-
dc.departmentİzmir Institute of Technology. Chemical Engineeringen_US
dc.departmentİzmir Institute of Technology. Food Engineeringen_US
dc.identifier.volume80en_US
dc.identifier.issue1-2en_US
dc.identifier.startpage37en_US
dc.identifier.endpage49en_US
dc.identifier.wosWOS:000341814600006en_US
dc.identifier.scopus2-s2.0-84894239853en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.1007/s10847-014-0396-4-
dc.relation.doi10.1007/s10847-014-0396-4en_US
dc.coverage.doi10.1007/s10847-014-0396-4en_US
local.message.claim2022-06-06T14:55:26.321+0300|||rp02965|||submit_approve|||dc_contributor_author|||None*
dc.identifier.wosqualityQ2-
dc.identifier.scopusqualityQ2-
item.languageiso639-1en-
item.grantfulltextopen-
item.fulltextWith Fulltext-
item.cerifentitytypePublications-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.dept03.02. Department of Chemical Engineering-
crisitem.author.dept03.08. Department of Food Engineering-
Appears in Collections:Chemical Engineering / Kimya Mühendisliği
Food Engineering / Gıda Mühendisliği
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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