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https://hdl.handle.net/11147/5793
Title: | The impact of Onco type DX® recurrence score of paraffin-embedded core biopsy tissues in predicting response to neoadjuvant chemotherapy in women with breast cancer | Authors: | Soran, Atilla Bhargava, Rohit Johnson, Ronald Ahrendt, Gretchen Bonaventura, Marguerite Diego, Emilia McAuliffe, Priscilla F. Serrano, Merida Menekşe, Ebru Sezgin, Efe McGuire, Kandace P. |
Keywords: | Breast cancer Estrogen positive Tumor volume reduction 21 gene assay Neoadjuvant therapy Antineoplastic agent |
Publisher: | IOS Press | Source: | Soran, A., Bhargava, R., Johnson, R., Ahrendt, G., Bonaventura, M., Diego, E., McAuliffe, P. F., Serrano, M., Menekşe, E., Sezgin, E., and McGuire, K. P. (2016). The impact of Onco type DX® recurrence score of paraffin-embedded core biopsy tissues in predicting response to neoadjuvant chemotherapy in women with breast cancer. Breast Disease, 36(2-3), 65-71. doi:10.3233/BD-150199 | Abstract: | BACKGROUND: Oncotype DX® test is beneficial in predicting recurrence free survival in estrogen receptor positive (ER+) breast cancer. Ability of the assay to predict response to neoadjuvant chemotherapy (NCT) is less well-studied. OBJECTIVE: We hypothesize a positive association between the Oncotype DX® recurrence score (RS) and the percentage tumor response (%TR) after NCT. METHODS: Pre-therapy RS was measured on core biopsies from 60 patients with ER+, HER2.. invasive breast cancer (IBC) who then received NCT. Pre-therapy tumor size was measured using imaging. %TR, partial response (PR; 50%), pathologic complete response (PCR) and breast conserving surgery (BCS) rates were measured. RESULTS: Median RS was 20 (2 69). Median %TR was 42 (0 97)%. PR was observed in 43% of patients. There was no association between %TR and pre-NCT tumor size, age, Nottingham score or nodal status (p 0:05). No statistically significant association with %TR was seen with RS as a categorical or continuous variable (p = 0:21 and 0.7, respectively). Response to NCT improved as ER (p = 0:02) by RT-PCR decreased. Lower ER expression by IHC correlated with response (p = 0:03). CONCLUSIONS: In patients with ER+ IBC receiving NCT, RS did not predict response to NCT using %TR. The benefit of the assay prior to NCT requires further study. | URI: | http://doi.org/10.3233/BD-150199 http://hdl.handle.net/11147/5793 |
ISSN: | 0888-6008 |
Appears in Collections: | Food Engineering / Gıda Mühendisliği PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection |
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