Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5998
Title: BODIPY-conjugated chitosan nanoparticles as a fluorescent probe
Authors: Bor, Gizem
Üçüncü, Muhammed
Emrullahoğlu, Mustafa
Tomak, Aysel
Şanlı Mohamed, Gülşah
Keywords: A549 cells
BEAS 2B cells
BODIPY
Chitosan
Cytotoxicity
Publisher: Taylor and Francis Ltd.
Source: Bor, G., Üçüncü, M., Emrullahoǧlu, M., Tomak, A., and Şanlı Mohamed, G. (2016). BODIPY-conjugated chitosan nanoparticles as a fluorescent probe. Drug and Chemical Toxicology. doi:10.1080/01480545.2016.1238481
Abstract: Recently, development of fluorescent nanoparticle-based probes for various bioimaging applications has attracted great attention. This work aims to develop a new type fluorescent nanoparticle conjugate and evaluate its cytotoxic effects on A549 and BEAS 2B cell lines. Throughout the study, ionically crosslinked chitosan nanoparticles (CNs) were conjugated with carboxylated 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY-COOH). The results of conjugates (BODIPY-CNs) were investigated with regard to their physic-chemical, optical, cytotoxic properties and cellular internalization. The morphology of BODIPY-CNs was found to be spherical in shape and quite uniform having average diameter of 70.25 ± 11.99 nm. Cytotoxicty studies indicated that although BODIPY-COOH itself was quite toxic on both A549- and BEAS 2B-treated cells, CNs increased the cell viability of both cell lines via conjugation to BODIPY-COOH fluorescent molecule up to 67% for A549 and 74% for BEAS 2B cells. These results may suggest a possible utilization of the new fluorescent nanoparticle-based probe for bioimaging in biology and medicine.
URI: http://doi.org/10.1080/01480545.2016.1238481
http://hdl.handle.net/11147/5998
ISSN: 0148-0545
0148-0545
Appears in Collections:Chemistry / Kimya
Materials Science and Engineering / Malzeme Bilimi ve Mühendisliği
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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