Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/7918
Title: Differential expression of toxoplasma gondii microRNAs in murine and human hosts
Authors: Saçar Demirci, Müşerref Duygu
Bağcı, Caner
Allmer, Jens
Issue Date: 2016
Publisher: Springer
Abstract: MicroRNAs are short RNA sequences involved in post-transcriptional gene regulation. MicroRNAs are known for a wide variety of species ranging from bacteria to plants. It has become clear that some cross-kingdom regulation is possible especially between viruses and their hosts. We hypothesized that intracellular parasites, like Toxoplasma gondii, similar to viruses would be able to modulate their host’s gene expression. We were able to show that T. gondii produces many putative pre-miRNAs which are actually transcribed. Furthermore, some of these expressed pre-miRNAs have a striking resemblance to host mature miRNAs. Previous studies indicated that T. gondii infection coincides with increased abundance of some miRNAs. Here we were able to show that many of these miRNAs have close relatives in T. gondii which may not be distinguishable using PCR. Taken together, the similarity to host miRNAs, their confirmed expression, and their upregulation during infection, it suggests that T. gondii actively transfers miRNAs to regulate its host. We conclude, that this type of cross-kingdom regulation may be possible, but that targeted analysis is necessary to consolidate our computational findings. © Springer International Publishing Switzerland 2016. All rights are reserved.
URI: https://doi.org/10.1007/978-3-319-39496-1_9
https://hdl.handle.net/11147/7918
ISBN: 9783319394961
Appears in Collections:Bioengineering / Biyomühendislik
Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection

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