The correlation of Magee Equations (TM) and Oncotype DX (R) recurrence score from core needle biopsy tissues in predicting response to neoadjuvant chemotherapy in ER+ and HER2- breast cancer

Abstract

Objective: Oncotype DX (R) recurrence score (RS) can be predicted from Magee Equations (TM) (MS) postoperatively. The aim of this study is to investigate correlation of MS with RS from pretreatment core needle biopsy (CNB) [issues, and their clinical usefulness in prediction of response to neoadjuvant chemotherapy (NCT) in estrogen receptor-positive and human epidermal growth factor receptor 2-negative (ER+/HER2-) breast cancer (BC). Materials and Methods: Prerrearmenr CNB tissue samples from 60 patients with ER+ /HER2- invasive BC were analyzed for MS and RS correlation. MS and RS were categorized as follows low (<18), intermediate (18-30), and high (>= 31). Percentage Tumor size Reduction (%TR) was used to assess tumor response to NCT, and substantial %TR was defined as at least 50% reduction (.50%TR). Correlation between MS and RS, and predictisv factors for the >= 50%TR achievement were assessed. Results: MS and RS represen red a strong correlation (Spearman's correlation; r-0.58, p<0.0001) as a continuous variable. As a categorical variable, the concordance between MS and RS was 43.3%, and it increased to 80% (r-0.61, p-0.003) with the exclusion of the intermediate risk categories. Although, there was pathologic complete response (pCR), MS showed the highest predictive power for the >= 50% TR achievemenr, none of the factors were Magically significant (p >= 0.07). Conclusion: Our study demonstrated that there was a strong correlation between MS and RS from pretreatment biopsy tissue samples in ER+ and HER2- invasive. BC.