Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/9298
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dc.contributor.authorUysal, Erdal-
dc.contributor.authorCeylan, Seyit Mehmet-
dc.contributor.authorSezgin, Efe-
dc.contributor.authorBakir, Hasan-
dc.contributor.authorGurer, Ahmet Orhan-
dc.contributor.authorAksoy, Basar-
dc.contributor.authorBastemir, Mehmet-
dc.date.accessioned2020-07-25T22:09:22Z-
dc.date.available2020-07-25T22:09:22Z-
dc.date.issued2017-
dc.identifier.issn2074-1804-
dc.identifier.issn2074-1812-
dc.identifier.urihttps://doi.org/10.5812/ircmj.58295-
dc.identifier.urihttps://hdl.handle.net/11147/9298-
dc.description.abstractBackground: Hemocytometer parameters can be important biomarkers for some types of cancers and diseases. There is a need to evaluate their biomarker potential in thyroid diseases. Objectives: The current study aimed at contributing to potential biomarker researches to diagnose papillary thyroid carcinoma (PTC) and benign multinodular goiter (BMG), evaluate the role of these markers to determine the PTC characteristics and contribute to clarification of controversial issues. Methods: The study was designed as a retrospective observational study. The study included 389 patients who underwent total thyroidectomy at private Sani Konukoglu hospital (Sanko University, School of Medicine, Gaziantep, Turkey) due to BMG or PTC diagnosis from November 2011 to May 2017. The study subjects were divided into 3 groups. Groups 1, 2, and 3 were subjects with BMG, PTC, and the control, respectively. The comparisons were made among the groups in terms of hemocytometer parameters. In the group with the thyroid papillary carcinoma diagnosis, the relationship between the hemocytometer parameters and the bilateral tumor presence, single-sided multicentrite, and tumor diameter (size) were investigated. Results: Red cell distribution width (RDW) levels were 15.50 +/- 2.39, 15.68 +/- 2.16, and 12.5 +/- 1.51 in the BMG, PTC, and control groups, respectively. Mean platelet volumes (MPV) were 7.97 +/- 1.19, 8.05 +/- 1.20, and 7.23 +/- 1.39 in the BMG, PTC, and control groups, respectively. MPV and RDW values were significantly lower in group 3 compared with the groups 1 and 2 (P < 0.0001). Plateletcrit (PCT) values were 0.22 +/- 0.05, 0.23 +/- 0.06, and 0.19 +/- 0.05 in the BMG, PTC, and control groups, respectively. PCT was significantly lower in the group 3 compared with the groups 1 and 2 (P = 0.0001). In PTC group, no significant relationship was observed between any of the examined hematological parameters in terms of multicentric and bilateral tumor presence. Conclusions: RDW, MPV, haemoglobin content, and PCT were significantly higher in the BMG and PTC groups. This increase was not specific for either of the 2 groups. No significant difference was found between any of the hemocytometer parameters and the multicentricity and bilaterality of PTC. But, a possible correlation was observed between activated partial thromboplastin time (aPTT), hemoglobin content, and tumor size.en_US
dc.language.isoenen_US
dc.publisherKowsar Publishing Companyen_US
dc.relation.ispartofIranian Red Crescent Medical Journalen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGoiteren_US
dc.subjectPapillary thyroid carcinomaen_US
dc.subjectNeutrophilen_US
dc.subjectLymphocyteen_US
dc.subjectPlateleten_US
dc.titleEvaluation of hemocytometer parameters as potential biomarkers in benign multinodular goiter and papillary thyroid carcinomaen_US
dc.typeArticleen_US
dc.authorid0000-0002-8000-7485-
dc.institutionauthorSezgin, Efe-
dc.departmentİzmir Institute of Technology. Food Engineeringen_US
dc.identifier.volume19en_US
dc.identifier.issue12en_US
dc.identifier.wosWOS:000428933600006en_US
dc.identifier.scopus2-s2.0-85044956504en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.doi10.5812/ircmj.58295-
dc.relation.doi10.5812/ircmj.58295en_US
dc.coverage.doi10.5812/ircmj.58295en_US
dc.identifier.wosqualityQ4-
dc.identifier.scopusqualityQ3-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.cerifentitytypePublications-
item.grantfulltextopen-
crisitem.author.dept03.08. Department of Food Engineering-
Appears in Collections:Food Engineering / Gıda Mühendisliği
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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