Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/5345
Title: Surface modification of polysulfone based hemodialysis membranes with layer by layer self assembly of polyethyleneimine/alginate-heparin: A simple polyelectrolyte blend approach for heparin immobilization
Authors: Yaşar Mahlıçlı, Filiz
Alsoy Altınkaya, Sacide
Keywords: Blood compatibility
Hemodialysis membranes
Heparin immobilization
Sulfonated polysulfone
Human plasma proteins
Membrane
Issue Date: Feb-2013
Publisher: Springer Verlag
Source: Yaşar Mahlıçlı, F., and Alsoy Altınkaya, S. (2013). Surface modification of polysulfone based hemodialysis membranes with layer by layer self assembly of polyethyleneimine/alginate-heparin: A simple polyelectrolyte blend approach for heparin immobilization. Journal of Materials Science: Materials in Medicine, 24(2), 533-546. doi:10.1007/s10856-012-4804-2
Abstract: This study intends to improve blood compatibility of polysulfone (PSF) membranes by generating a nonthrombogenic surface through heparin immobilization. To achieve this task, the support membrane prepared from a blend of PSF and sulfonated polysulfone (SPSF) was modified with layer by layer (LBL) deposition of polyethyleneimine (PEI) and alginate (ALG) and heparin blended with ALG was immobilized only on the outermost surface of the LBL assembly. The results have shown that the adsorption of human plasma proteins and platelet activation on the LBL modified membranes decreased significantly compared with the unmodified PSF and PSF-SPSF blend membranes. Furthermore, blending ALG with a small amount of heparin remarkably prolonged the APTT values of heparin free PEI/ALG coated membranes. It is envisaged that the use of a blend of HEP and ALG only in the terminating layer of the LBL assembly can be an economical and alternative modification technique to create nonthrombogenic surfaces.
URI: https://doi.org/10.1007/s10856-012-4804-2
http://hdl.handle.net/11147/5345
ISSN: 0957-4530
Appears in Collections:Chemical Engineering / Kimya Mühendisliği
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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