Please use this identifier to cite or link to this item: https://hdl.handle.net/11147/7693
Title: Use of microRNAs in personalized medicine
Authors: Avcı, Çığır Biray
Baran, Yusuf
Keywords: miRNAs
Personalized medicine
Pharmacogenomics
Messenger RNA
Issue Date: 2014
Publisher: Humana Press
Source: Avcı, Ç. B., and Baran, Y. (2014). Use of microRNAs in personalized medicine. Methods in Molecular Biology, 1107, 311-325. doi:10.1007/978-1-62703-748-8_19
Abstract: Personalized medicine comprises the genetic information together with the phenotypic and environmental factors to yield healthcare tailored to an individual and removes the limitations of the "one-size-fits-all" therapy approach. This provides the opportunity to translate therapies from bench to clinic, to diagnose and predict disease, and to improve patient-tailored treatments based on the unique signatures of a patient's disease and further to identify novel treatment schedules. Nowadays, tiny noncoding RNAs, called microRNAs, have captured the spotlight in molecular biology with highlights like their involvement in DNA translational control, their impression on mRNA and protein expression levels, and their ability to reprogram molecular signaling pathways in cancer. Realizing their pivotal roles in drug resistance, they emerged as diagnostic targets orchestrating drug response in individualized therapy examples. It is not premature to think that researchers could have the US Food and Drug Administration (FDA)-approved kit-based assays for miRNA analysis in the near future. We think that miRNAs are ready for prime time.
URI: https://doi.org/10.1007/978-1-62703-748-8_19
https://hdl.handle.net/11147/7693
ISSN: 1064-3745
1940-6029
1064-3745
Appears in Collections:Molecular Biology and Genetics / Moleküler Biyoloji ve Genetik
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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